Prof.dr. M. Peppelenbosch

Biography

Following a summer internship at Faculty of Physics at Kraków Jagiellonian University (1985) I joined the Faculty of Medicine at Utrecht University, where I specialised in medical biology. Subsequently, I performed a Ph.D. research at the Hubrecht Laboratory, this research I pursued how  receptor tyrosine kinase signalling harnesses increased production of inflammatory lipids (leukotrienes, prostaglandins) for cytoskeletal remodelling, cell migration and immune evasion. The experience gained allowed me to obtain a KWF fellowship and I went to Anne Ridley laboratory (London) and to Walter Fiers (Vlaams Instituut voor Biotechnology) where I specialised myself in cell biology. Based on this experience I was allowed to set up my own research line at the Laboratory of Experimental Internal Medicine (AMC), where I established a highly visible group in experimental gastroenterology. Important topics of research were the role of morphogen signalling and vitamin signalling, the role of kinases in inflammation and cardiovascular disease, and the mechanism of action by anti-TNFα antibodies.

In 2004, I became professor in Cell Biology in Groningen (the youngest full professor in The Netherlands at the time). Also tempted, however, by the possibility to take an active role in establishing the joint Bachelor programme of the Erasmus University of Rotterdam, Leiden University and the TU Delft in Clinical Technology in 2009 I moved my research group to Rotterdam. I became  head of the laboratory for Gastroenterology and Hepatology. which hosts investigators from the Departments of Gastroenterology and Hepatology, Surgery, and Internal Medicine.  Currently my research focusses on the mechanisms that mediate progression towards cancer and their potential use for early detection and prevention of disease.Following a summer internship at Faculty of Physics at Kraków Jagiellonian University (1985) I joined the Faculty of Medicine at Utrecht University, where I specialised in medical biology. Subsequently, I performed a Ph.D. research at the Hubrecht Laboratory, this research I pursued how  receptor tyrosine kinase signalling harnesses increased production of inflammatory lipids (leukotrienes, prostaglandins) for cytoskeletal remodelling, cell migration and immune evasion. The experience gained allowed me to obtain a KWF fellowship and I went to Anne Ridley laboratory (London) and to Walter Fiers (Vlaams Instituut voor Biotechnology) where I specialised myself in cell biology. Based on this experience I was allowed to set up my own research line at the Laboratory of Experimental Internal Medicine (AMC), where I established a highly visible group in experimental gastroenterology. Important topics of research were the role of morphogen signalling and vitamin signalling, the role of kinases in inflammation and cardiovascular disease, and the mechanism of action by anti-TNFα antibodies.

In 2004, I became professor in Cell Biology in Groningen (the youngest full professor in The Netherlands at the time). Also tempted, however, by the possibility to take an active role in establishing the joint Bachelor programme of the Erasmus University of Rotterdam, Leiden University and the TU Delft in Clinical Technology in 2009 I moved my research group to Rotterdam. I became  head of the laboratory for Gastroenterology and Hepatology. which hosts investigators from the Departments of Gastroenterology and Hepatology, Surgery, and Internal Medicine.  Currently my research focusses on the mechanisms that mediate progression towards cancer and their potential use for early detection and prevention of disease.